Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal bleeding	Bruising susceptibility	Juvenile myelomonocytic leukemia	Abnormality of coagulation	Reduced factor XIII activity	Reduced factor XII activity	Abnormal platelet function	Amegakaryocytic thrombocytopenia	Abnormality of the spleen
Disease(s) Associated with PTPN11	Abnormal bleeding	Bruising susceptibility	Juvenile myelomonocytic leukemia	Abnormality of coagulation	Reduced factor XIII activity	Reduced factor XII activity	Abnormal platelet function	Amegakaryocytic thrombocytopenia	Abnormality of the spleen
juvenile myelomonocytic leukemia
Noonan syndrome
Noonan syndrome 1

Mouse Phenotypes

hematopoietic system phenotype

enlarged spleen

increased spleen weight

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

decreased common myeloid progenitor cell number

abnormal erythropoiesis

abnormal leukopoiesis

arrested B cell differentiation

myeloid hyperplasia

extramedullary hematopoiesis

anemia

abnormal bone marrow cell morphology/development

abnormal bone marrow cell number

decreased bone marrow cell number

decreased granulocyte monocyte progenitor cell number

increased neutrophil cell number

increased granulocyte number

increased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

intermingled spleen red and white pulp

abnormal splenic cell ratio

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Ptpn11^tm7Bgn/Ptpn11^tm7Bgn

Ptpn11^tm1.1Ics/Ptpn11⁺

Ptpn11^tm1Bgn/Ptpn11⁺

Ptpn11^tm4.2Bgn/Ptpn11⁺

Ptpn11^tm7Bgn/Ptpn11⁺

Ptpn11^tm1Ckq/Ptpn11⁺
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Ptpn11^tm1Ckq/Ptpn11⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Ptpn11^tm6Bgn/Ptpn11⁺
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Ptpn11^tm6Bgn/Ptpn11⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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